In young patients, irreparable subscapularis tears can be managed by latissimus dorsi (LD) transfer on the lesser tuberosity.We provide a technical guide for isolated LD anterior transfer.The surgical procedure begins with glenohumeral exploration and release of the remaining subscapularis.Then, we dissect the LD tendon below the subscapularis.At t
Lipidomic Profiling Identifies a Novel Lipid Signature Associated with Ethnicity-Specific Disparity of Bladder Cancer
Bladder Cancer (BLCA) is the ninth most frequently diagnosed cancer globally Drone and the sixth most common cancer in the US.African Americans (AA) exhibit half the BLCA incidence compared to European Americans (EA), but they have a 70% higher risk of cancer-related death; unfortunately, this disparity in BLCA mortality remains poorly understood.I
Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family
The potassium channel Kv1.3, involved in several important pathologies, is the target of a family of psoralen-based drugs whose mechanism of action is not fully understood.Here we provide evidence for a physical Elbow Support interaction of the mitochondria-located Kv1.3 (mtKv1.3) and Complex I of the respiratory chain and show that this proximity